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Lansoprazole; Amoxicillin; Clarithromycin Tablets and Capsules

What is this medicine?

LANSOPRAZOLE; AMOXICILLIN; CLARITHROMYCIN (lan SOE pra zole; a mox i SIL in; kla RITH roe mye sin) is a combination of three medicines used to treat ulcers associated with a bacterial infection.

How should I use this medicine?

Take these medicines by mouth with a full glass of water. Each dose should be taken twice per day before eating. Follow the directions on the prescription label. Do not crush or chew. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not skip doses or stop your medicine early even if you feel better. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • bloody or watery diarrhea

  • breathing problems

  • confusion

  • dizziness

  • rash, fever, and swollen lymph nodes

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

  • signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast or irregular heartbeat; palpitations; feeling faint or lightheaded, falls; breathing problems

  • signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine

  • signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin

  • stomach polyps

  • vaginal discharge, itching, or odor in women

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • changes in taste

  • diarrhea

  • dry mouth, thirst

  • headache

  • mouth sores

  • muscle pain

  • nausea, vomiting

  • stomach pain

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • certain medicines for cholesterol like cerivastatin, lovastatin, simvastatin

  • certain medicines for HIV or AIDS like atazanavir, nelfinavir, rilpivirine, saquinavir

  • cisapride

  • conivaptan

  • dihydroergotamine, ergotamine

  • dofetilide

  • dronedarone

  • eletriptan

  • eplerenone

  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine

  • flibanserin

  • ivabradine

  • lomitapide

  • lurasidone

  • naloxegol

  • pimozide

  • posaconazole

  • ranolazine

  • silodosin

  • tolvaptan

  • red yeast rice

  • thioridazine

  • ziprasidone

This medicine may also interact with the following medications:

  • alfentanil

  • bromocriptine

  • certain medicines for anxiety or sleep

  • certain medicines for blood pressure

  • certain medicines for diabetes

  • certain medicines for erectile dysfunction

  • certain medicines for fungal infections

  • certain medicines for irregular heart beat

  • certain medicines for seizures

  • certain medicines that treat or prevent blood clots like warfarin

  • cilostazol

  • colchicine

  • cyclosporine

  • digoxin

  • disopyramide

  • erlotinib

  • female hormones, like estrogens or progestins and birth control pills

  • iron supplements

  • methotrexate

  • methylprednisolone

  • mycophenolate

  • other medicines for cholesterol

  • other medicines for HIV or AIDS

  • other medicines for infections

  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)

  • St. John's Wort

  • sucralfate

  • tacrolimus

  • theophylline

  • tolterodine

  • vinblastine

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light and moisture. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • heart disease

  • history of irregular heartbeat

  • kidney disease

  • liver disease

  • lupus

  • myasthenia gravis

  • an unusual or allergic reaction to lansoprazole, amoxicillin, clarithromycin, other antibiotics, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care provider for regular check ups. Tell your doctor or if your symptoms do not improve or if they get worse.

This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

Call your doctor as soon as you can if you get a fever, watery diarrhea, stomach pain, or vomiting. These could be symptoms of a more serious illness. Do not treat yourself. Call your doctor for advice.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.

If you are diabetic you may get a false-positive result for sugar in your urine. Talk to your health care provider.

This medicine may cause a decrease in vitamin B12. You should make sure that you get enough vitamin B12 while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care provider.

NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2021 Elsevier
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